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Life sciences · Journal article
BMC Cardiovascular Disorders · September 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This single-center retrospective observational study of 260 hospitalized medical patients in Ethiopia found that 57% met high-risk criteria for VTE by Padua Prediction Score, but only 62% of those receiving prophylaxis were treated appropriately according to the score. Cardiovascular disease, bed rest, and CNS disorders were associated with inappropriate prophylaxis use, but the study is descriptive and does not measure clinical outcomes or test an intervention.
Retrospective observational study. Hospitalized medical patients at Tikur Anbessa Specialized Hospital in Addis Ababa, Ethiopia; 260 patients enrolled (53.1% male). Specific eligibility criteria for medical vs. surgical status and exclusions were not detailed.. n = 260. Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia.
57% (95% CI 46.7%–66.7%) of hospitalized medical patients were at high risk for VTE by Padua Prediction Score Among patients treated with thromboprophylaxis, only 62% (95% CI 55.7%–67.8%) were appropriately treated according to PPS High-risk patients with cardiovascular disease were three times likely to receive inappropriate prophylaxis (AOR 3.06, 95% CI 1.12–8.86, p < 0.05)
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This study identifies gaps in appropriate thromboprophylaxis use in a resource-limited setting and flags patient subgroups (cardiovascular disease, immobility, CNS disorders) where prescribing deviates from risk stratification tools. Clinicians should recognize that guideline adherence varies by patient phenotype and that re-education or decision support may improve appropriateness, though this study does not test interventions to close these gaps.
Single-center retrospective observational study assessing appropriateness of thromboprophylaxis practice using a validated scoring tool, but without a comparator arm or intervention trial; findings are descriptive and hypothesis-generating rather than practice-testing.
As stated by the source record.
Quoted from the source exactly as published.
This study identifies gaps in appropriate thromboprophylaxis use in a resource-limited setting and flags patient subgroups (cardiovascular disease, immobility, CNS disorders) where prescribing deviates from risk stratification tools. Clinicians should recognize that guideline adherence varies by patient phenotype and that re-education or decision support may improve appropriateness, though this study does not test interventions to close these gaps.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Hospitalization increases the chance of developing venous thromboembolism. Moreover, the risk of thromboembolism of the veins will be increased by co-morbidities, surgery, and current infections, which emphasizes the necessity of meticulous evaluation of high-risk patients and proper pharmacological prophylaxis in order to prevent venous thromboembolism and enhance the outcome of therapy. This study aimed to assess the appropriateness of venous thromboembolism prophylaxis and its associated factors among hospitalized medical patients. A retrospective observational study was conducted from January 2023 to December 2023 on medical patients at Tikur Anbessa Specialized Hospital (TASH). The Padua Prediction Score (PPS) was used to assess the risk and eligibility of thromboprophylaxis among the participants. Descriptive statistics were performed to describe the explanatory and outcome variables. Bivariable and multivariable analysis and Fisher exact tests were performed to assess the factor association with venous thromboembolism prophylaxis. A p-value < 5% was set for statistical significance. A total of 260 patients were included in this study. More than half of the participants,138(53.1%), were male. According to Padua prediction score, 57% (95% CI 46.7%-66.7%) of hospitalized medical patients were at high risk for developing venous thromboembolism. Among the patients treated with thromboprophylaxis, only 62% (95% CI 55.7%-67.8%) of the participants were appropriately treated with venous thromboprophylaxis according to PPS score. Patients with recent surgery or trauma, bed rest or immobility and active cancer were identified as factors associated with inappropriate use of thromboprophylaxis. The study showed that participants with high risk group(PPS ≥ 4) who had cardiovascular diseases were three times likely (AOR, 3.06 95% CI 1.12–8.86, p < 0.05) to be given thromboprophylaxis inappropriately compared to patients with no history of cardiovascular. Moreover, in low risk group participants (PPS < 4), the participants with bed rest or immobility (p value = 0.004), cardiovascular diseases(p value = 0.04) and CNS disorders(p value = 0.045) were significantly associated with inappropriate thromboprophylaxis treatment among hospitalized patients. More than half of hospitalized medical patients were at risk of developing venous thromboembolism. And more than one third of participants were inappropriately treated with venous thromboprophylaxis. Patients with cardiovascular diseases, bed rest or immobility, CNS disorders were more likely to be treated with thromboprophylaxis inappropriately based on the Padua predictive score.
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