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Life sciences · Observational Study
ClinicalTrials.gov · November 9, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07924501). This is a study registration, not published results. Lead sponsor: Second Affiliated Hospital of Guangzhou Medical University. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 240 participants (ESTIMATED). Conditions: Sepsis, Septic Shock, Septic Cardiomyopathy. Interventions: OTHER: Point-of-care echocardiography. Primary outcome measures: Echocardiography-Derived Hemodynamic Phenotypes in Adults With Septic Shock , Within 7 days after enrollment. Brief summary: This is a prospective, single-center, observational cohort study. The purpose of this study is to investigate the hemodynamic heterogeneity and dynamic evolution patterns in patients with septic shock, using point-of-care echocardiography combined with artificial intelligence technology. The study will enroll 240 adult patients with septic shock admitted to the ICU. Standardized cardiac ultrasound examinations will be performed at multiple time points, and multi-dimensional clinical-echocardiographic data will be collected. An AI-based automatic echocardiographic analysis system will be developed, and unsupervised machine learning will be applied to identify distinct hemodynamic subtypes and their dynamic evolution trajectories. This study aims to provide innovative solutions for individualized and precise hemodynamic management of septic shock.