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Sham Stimulation / Depressive Disorder, Major / Left Dorsolateral Prefrontal Cortex (L-DLPFC) · Interventional Study
ClinicalTrials.gov · August 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registered interventional trial, currently recruiting, that will evaluate accelerated intermittent theta-burst stimulation (aiTBS) targeting the left dorsolateral or dorsomedial prefrontal cortex versus sham in patients with borderline personality disorder and concurrent depressive episodes. No efficacy or safety results are posted in this registry record; the trial remains ongoing.
Interventional, Randomized, Parallel, Quadruple masking, Treatment purpose. Depressive Disorder, Major, Borderline Personality Disorder; age from 18 Years; to 80 Years. Intervention: Left Dorsolateral Prefrontal Cortex (L-DLPFC); Dorsomedial Prefrontal Cortex (DMPFC). Compared with: Sham stimulation — Sham Comparator. n = 45. 1 site: United States.
This is a registered interventional trial, currently recruiting, that will evaluate accelerated intermittent theta-burst stimulation (aiTBS) targeting the left dorsolateral or dorsomedial prefrontal cortex versus sham in patients with borderline personality disorder and concurrent depressive episodes. No efficacy or safety results are posted in this registry record; the trial remains ongoing.
This is a registry record only; no efficacy, safety, or outcome data are reported.
Clinicians should await completion and publication of results before considering aiTBS as an evidence-based treatment for depression in BPD. This trial addresses an understudied combination and may inform future treatment algorithms if positive.
This is a recruiting interventional trial with no posted results; it represents early-phase evaluation of an accelerated rTMS protocol in a specific BPD population with planned n=45.
As stated by the source record.
Quoted from the source exactly as published.
Clinicians should await completion and publication of results before considering aiTBS as an evidence-based treatment for depression in BPD. This trial addresses an understudied combination and may inform future treatment algorithms if positive.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT04870255). This is a study registration, not published results. Lead sponsor: Stanford University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 45 participants (ESTIMATED). Conditions: Depressive Disorder, Major, Borderline Personality Disorder. Interventions: DEVICE: Left Dorsolateral Prefrontal Cortex (L-DLPFC); DEVICE: Dorsomedial Prefrontal Cortex (DMPFC); DEVICE: Sham Stimulation. Primary outcome measures: Change in the clinician rated Montgomery-Asberg Depression Rating Scale (MADRS-C) in active L-DLPFC vs. sham aiTBS. , At baseline (pre-intervention), during the intervention and immediately after the intervention.. Brief summary: This study evaluates the antidepressant effects of an accelerated schedule of theta-burst stimulation, termed accelerated intermittent theta-burst stimulation (aiTBS), in individuals with borderline personality disorder (BPD) or trait and comorbid mood depressive disorder (MDD) or bipolar II disorder in a current mood depressive episode (MDE).
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.