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Life sciences · Preprint
arXiv · October 13, 2026
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Recently, Morris et al. introduced TinyLoRA, a strategy for LLM fine-tuning which introduces arbitrarily few parameters, and demonstrated accuracy improvements using less than $10$ parameters rather than the ${\gtrsim 10,000}$ typically demanded by LoRA-based methods. However, that study continued to use gradient-based local search methods of the kind deployed for training multi-billion parameter LLMs in the first place. This article is predicated on the observation that, in the low dimensional setting, global optimization methods become tractable, unlocking Large language Model Bayesian Optimization (LlMBO). LlMBO is sample-efficient, gradient-free, memory-light, parallelizes across devices without synchronization, and, unlike policy-gradient methods, can optimize greedy-decoding accuracy directly. We describe numerical experiments comparing LlMBO against GRPO on fine-tuning tasks for a variety of models on a math benchmark suite which show that LlMBO can be a suitable alternative in this regime, matching or exceeding GRPO's fine tuning gains, while using a fraction of the compute and memory.