Loading
Life sciences · Journal article
Frontiers in Public Health · October 26, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Background Respiratory Syncytial Virus (RSV) remains a significant public health concern globally, with distinct seasonal patterns in temperate regions, while tropical settings experience RSV year-round with seasonal fluctuations. This study investigated seasonality and exogenous factors influencing RSV cases among hospitalized children under 12 years in Negeri Sembilan, Malaysia. Methods Weekly laboratory-confirmed RSV-positive cases among hospitalized pediatric patients presenting with acute lower respiratory tract infections (LRTIs) across 417 continuous WHO epidemiological weeks (EpiWeek 1, 2017 to EpiWeek 52, 2024) were analyzed using decomposition and autocorrelation functions. Relationships between RSV and co-circulating viruses, meteorological variables, and holidays were assessed via cross-correlation and Autoregressive Integrated Moving Average with Exogenous variables (ARIMAX) modeling. Results A total of 6,545 (14.29%) samples were RSV-positive from a total of 45,817 tested. Historical peaks (July–September) were disrupted during 2020–2023 but re-established in 2024. The ARIMAX (2,0,4) (1,0,0) 52 model revealed that RSV dynamics were driven primarily by internal autoregressive patterns rather than meteorological factors. Major public holidays exhibited a significant dual effect, with an immediate decrease in reported cases ( p = 0.012) followed by a significant surge ( p = 0.014). Influenza activity was a significant predictor with a one-week lag ( p = 0.012). Conclusion The pandemic temporarily shifted RSV seasonality, which has since normalized. The associations with holiday periods and influenza activity suggests that behavioral factors and viral interference may influence RSV circulation. These findings emphasize the need for dynamic surveillance to optimize the timing of future RSV immunizations in Malaysia.