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Life sciences · Observational Study
ClinicalTrials.gov · September 15, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07820267). This is a study registration, not published results. Lead sponsor: Assiut University. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 120 participants (ESTIMATED). Conditions: Respiration Failure, Diaphragmatic Dysfunction, Mechanical Ventilation, Septic Shock. Primary outcome measures: Number of participants Developing Respiratory Failure Requiring Invasive Mechanical Ventilation. , From Baseline through Day 7; Diaphragmatic Excursion Measured by Point of Care ultrasound , Baseline, 24 hours, 48 hours, and 72 hours; Diaphragmatic Thickness Measured by Point of Care Ultrasound , Baseline, 24 hours, 48 hours, and 72 hours; Diaphragmatic Thickening Fraction Measured by Point of Care Ultrasound , Baseline, 24 hours, 48 hours, and 72 hours. Brief summary: This prospective observational cohort study aims to evaluate the prognostic value of serial bedside ultrasound assessment of diaphragmatic function in adult patients with septic shock. Diaphragmatic excursion, thickness, and thickening fraction will be assessed using point of care ultrasound at baseline and serially during the first 72 hours of intensive care admission. Dynamic changes in these parameters will be analyzed in relation to the development of respiratory failure, need for invasive mechanical ventilation, duration of mechanical ventilation, weaning and extubation outcomes, length of ICU stay, and mortality. The study will determine whether dynamic diaphragmatic ultrasound assessment can provide an early, non-invasive predictor of respiratory failure and adverse clinical outcomes in patients with septic shock.