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Life sciences · Interventional Study
ClinicalTrials.gov · September 29, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06050070). This is a study registration, not published results. Lead sponsor: University of Michigan. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 45 participants (ACTUAL). Conditions: Major Depressive Disorder. Interventions: OTHER: FMRI with sham controlled feedback; OTHER: FMRI with real time feedback. Primary outcome measures: Blood Oxygen Level Dependent (BOLD) signal change during the active > passive contrast during the localizer session , Approximately 40 minutes (during MRI); BOLD signal change during the active>passive contrast, comparing baseline with transfer runs (no NF in either), during the real time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) session , Approximately 40 minutes (during MRI). Brief summary: The purpose of this study is to develop a technique called real time fMRI neurofeedback. This technique uses a regular MRI scanner, except that special software allows the researchers to measure activity in participants brain, using fMRI, and then give information, in the form of a feedback signal, which indicates brain activity in real time, while in the MRI scanner. The larger goal of this study is to develop ways to help people, including those with depression, better regulate brain activity. The researchers think that this may be helpful in managing psychiatric symptoms. This study design has three phases, however, only two phases (phase 2 and 3) are considered to be a clinical trial. Phase 2 (part 2) was registered and is NCT05934604. This is the phase 3 (part 3) for this project and is funded by the National Institutes of Health.