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Life sciences · Journal article
International Journal of Drug Delivery Technology · October 15, 2026
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The purpose of this review is to investigates the progression and effectiveness of colon-targeted drug delivery systems, offering a comprehensive understanding of the colon's anatomy and physiological environment.All figures designed using by Bio-render website.The Colon is a site where both local and systemic delivery of drugs can take place.To attain the successful Colon targeting drug delivery system, a drug must be protected from degradation in the upper portion of the GIT and then to be ensured abrupt or Controlled release in the proximal colon.The article outlines several approaches.pH controlled drug release.Prodrug approach.Time controlled drug delivery.Osmotically controlled drug delivery.Microbially triggered controlled drug delivery.Enzyme controlled drug delivery.Novel drug delivery system.The precision medicine play an important role in the cancer therapy.Although precision medicine have resulted in some clinical successes, the use of many potential therapeutics has been hindered by pharmacological issues, including toxicities and drug resistance.By using various approaches and precision medicines may be the best way to cure colon diseases using an optimized colon drug delivery system.Keywords: pH-controlled drug release.Prodrug approach.Time controlled drug