Loading
MATCHED PUFA DIET / Overweight and Obesity / COTTONSEED OIL · Interventional Study
ClinicalTrials.gov · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registered, recruiting interventional trial comparing cottonseed oil to a polyunsaturated fatty acid-matched diet and control on fasting and postprandial lipid metabolism over 28 days in 90 participants with dyslipidemia, overweight/obesity, or healthy status. The registry record contains only the protocol; no results are reported, and the evidence base is therefore empty.
Interventional, Randomized, Parallel, Double masking, Prevention purpose. Dyslipidemia, Overweight and Obesity, Nutrition, Healthy; age from 25 Years; to 75 Years; accepts healthy volunteers. Intervention: COTTONSEED OIL; MATCHED PUFA DIET. Compared with: CONTROL — Active Comparator. n = 90. 1 site: United States.
This is a registered, recruiting interventional trial comparing cottonseed oil to a polyunsaturated fatty acid-matched diet and control on fasting and postprandial lipid metabolism over 28 days in 90 participants with dyslipidemia, overweight/obesity, or healthy status. The registry record contains only the protocol; no results are reported, and the evidence base is therefore empty.
This is a registry record with no results posted; no efficacy, safety, or outcome data are available.
The source did not state who this applies to in practice.
This is a recruiting interventional trial with no results posted; it is a study protocol registration describing planned enrollment, design, and outcome measures only.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06382298). This is a study registration, not published results. Lead sponsor: University of Georgia. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 90 participants (ESTIMATED). Conditions: Dyslipidemia, Overweight and Obesity, Nutrition, Healthy. Interventions: OTHER: COTTONSEED OIL; OTHER: MATCHED PUFA DIET; OTHER: CONTROL. Primary outcome measures: Change in fasting serum lipoprotein and cholesterol concentrations , baseline, 4 weeks; Change in fasting and postprandial plasma triglyceride concentrations , baseline, 4 weeks; Change in fasting and postprandial plasma non-esterified fatty acid (NEFA) concentrations , baseline, 4 weeks. Brief summary: Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden. Cottonseed oil (CSO) is found readily in the food supply, and the investigator's previous studies have demonstrated that incorporating CSO into the diet is sufficient to improve fasting cholesterol profile and improve postprandial lipid and/or glycemic responses in both healthy, and at-risk populations. This study aims to compare CSO to a fatty acid composition-matched diet, on changes in fasting and postprandial lipid metabolism and markers of chronic disease risk. The specific aims are: * Examine the impact of CSO vs. PUFA on fasting and postprandial lipids. * Examine the impact of CSO on other markers of chronic disease risk. Participants will be asked to: * Consume provided meal replacement shakes daily for 28-days. * Attend three weekly short visits for fasting blood draws, body measurements, and collect the next week of study materials, * Attend two longer (5.5h) testing visits which include eating a standardized breakfast meal and having blood drawn periodically before and after breakfast. Researchers will compare CSO vs. PUFA and control groups (receiving a mixture of oils) to see if CSO is unique in imparting health benefits when compared with similar matched oil diets.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.