Life sciences · Preprint
arXiv · November 2, 2026
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As control engineering is applied to increasingly complex systems, learning-based control, which uses empirical data to reduce the reliance on first-principles models, has emerged as a promising paradigm. However, such approaches must cope with nonlinear and stochastic dynamics, the absence of state measurements, and scarce data, while ensuring safe operation under constraints, which requires rigorous uncertainty quantification. Whereas existing methods treat these challenges in isolation, this article proposes a Bayesian framework that jointly addresses them. A prior in state-space form is updated from input-output data using particle Markov chain Monte Carlo methods, yielding a representation of joint uncertainty over dynamics and latent states. Building on this representation, a validation procedure is developed that provides probabilistic guarantees for constraint satisfaction under arbitrary causal control laws. For control synthesis, a formulation penalizing the conditional value-at-risk of the constraint function is proposed, together with an adaptive calibration mechanism that adjusts the performance-robustness trade-off to achieve a desired robustness level. The probability of successful certification is characterized theoretically. The framework is extended to a receding-horizon setting, where posterior updates from new measurements allow the controller to progressively reduce uncertainty and improve performance. The approach is demonstrated on the optimal control of a vertical farm.