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Life sciences · Interventional Study
ClinicalTrials.gov · October 9, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07273942). This is a study registration, not published results. Lead sponsor: Hospices Civils de Lyon. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 720 participants (ESTIMATED). Conditions: Adult Patients With Septic Shock Admitted in Intensive Care Unit. Interventions: OTHER: Remote ischemic conditioning; OTHER: No intervention. Primary outcome measures: All-cause mortality at day 90 after inclusion , 90 days after inclusion. Brief summary: Septic shock is a leading cause of death worldwide despite intensive research efforts. Only a few interventions have been proven to be effective in improving patient-centered outcomes. Recent clinical trials have reported the safety and efficacy of remote ischemic postconditioning (RIPOST) in a variety of pathologies, including myocardial infarction, cardiac surgery, and stroke. While RIPOST was mainly tested in pathologies with low mortality rates, several follow-up studies of large randomized clinical trials in acute myocardial infarction and in patients undergoing coronary artery bypass surgery have reported significant decreases (\> 50%) in long-term mortality. Experimental studies and proof-of-concept clinical trials have also suggested the potential benefits of RIPOST on mortality in sepsis and septic shock. The present protocol aims to test whether this non-invasive, widely available, inexpensive, and innovative intervention can improve survival in septic shock.