Life sciences · Preprint
arXiv · October 9, 2026
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Traditional system identification typically involves two steps: initially, training data is processed to estimate a model of the system of interest; then, the model is used to predict outputs for new input queries. In contrast, recent in-context learning approaches learn a meta model that maps directly from training data and query inputs to outputs in a zero-shot fashion, bypassing explicit model estimation. This approach leverages a meta model trained offline, on large sets of synthetically generated data, to emulate the behavior of a system identification algorithm. In this work, we advance this meta-learning framework for system identification in three directions. First, we develop a unified probabilistic meta-identification architecture that combines a Transformer-based encoder-decoder with tailored mechanisms for handling long training sequences, enabling calibrated predictions over long horizons. Second, we show how a pre-trained meta model can act as an uncertainty-aware synthetic data generator for classical system identification, providing task-specific data that regularize parametric models when real data are scarce. Third, we systematically evaluate the framework on standard nonlinear system identification benchmarks and on a challenging out-of-distribution scenario, demonstrating competitive accuracy with state-of-the-art methods and strong generalization, including cases where input-only adaptation is sufficient to handle significant distribution shifts.