Loading
Life sciences · Interventional Study
ClinicalTrials.gov · October 22, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Interventional Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07888387). This is a study registration, not published results. Lead sponsor: Ruijin Hospital. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 15 participants (ACTUAL). Conditions: Major Depressive Disorder (MDD). Interventions: DEVICE: Temporal Interference Stimulation; DEVICE: Temporal Interference Stimulation; DEVICE: Temporal Interference Stimulation; DEVICE: Temporal Interference Stimulation; DEVICE: Temporal Interference Stimulation. Primary outcome measures: Number of Participants Who Completed All Five Stimulation Sessions , Up to 5 weeks; Number of Participants With Adverse Events , Up to 5 weeks; Participant-Reported Discomfort During Stimulation , Immediately after each of the five weekly sessions (Weeks 1-5); Change in resting-state functional connectivity , Immediately before and after each stimulation session. Brief summary: This pilot feasibility study used a randomized, double-blind, within-subject crossover design to explore temporal interference (TI) stimulation in adults with major depressive disorder. Fifteen participants received five weekly 20-minute stimulation sessions in randomized order, including TI stimulation targeting the left dorsolateral prefrontal cortex, left subgenual anterior cingulate cortex, right amygdala, and right ventral striatum, as well as a sham stimulation condition. The primary aim was to establish the feasibility of target-specific TI stimulation and to characterize its effects on functional connectivity and cognitive-emotional processing, assessed by resting-state fMRI and an emotional Stroop task before and after each session. Depressive and anxiety symptoms (HAMD and HAMA) were collected longitudinally across the five-week protocol as a secondary, exploratory measure.