Life sciences · Phase 2 Trial
ClinicalTrials.gov · October 26, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT04535960). This is a study registration, not published results. Lead sponsor: University Health Network, Toronto. Recruitment status: COMPLETED. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 6 participants (ACTUAL). Conditions: Type 2 Diabetes Mellitus. Interventions: DRUG: Empagliflozin 25 MG + Liraglutide 1.8 MG; DRUG: Liraglutide 1.8 MG + Empagliflozin 25 MG. Primary outcome measures: Proximal tubular natriuresis , up to 12 weeks. Brief summary: This study aims to provide essential mechanistic insights into natriuretic and hemodynamic effects of SGLT2i and GLP-1RA agents in T2D patients. Ultimately, by obtaining physiological data in T2D patients without HF, our aims are to gain insight into how the use of this combined therapy may be used in T2D with HF in future work.