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Life sciences · Interventional Study
ClinicalTrials.gov · November 4, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07216326). This is a study registration, not published results. Lead sponsor: Ann & Robert H Lurie Children's Hospital of Chicago. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 300 participants (ESTIMATED). Conditions: Depressive Symptoms, Allostatic Load, Metabolic Syndrome. Interventions: BEHAVIORAL: Racial Justice Activism Intervention ARM; BEHAVIORAL: Adulting 101- Control Arm. Primary outcome measures: Depressive Symptoms , at baseline and then 0-1-, 6-, 12-, 18-, and 24- months post initial 5 day-intervention; Metabolic Syndrome , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Blood Pressure , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Triglycerides , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; High-density lipoprotein , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Glycosylated hemoglobin , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Glucose , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Insulin , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention; Waist Circumference , at baseline and then 6-, 12-, and 24- months post initial 5 day-intervention. Brief summary: Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD). SRD manifests as policies and practices (e.g., redlining, voter suppression, mass incarceration) that produce hostile environments that contribute to psychological distress, elevated allostatic load, and an elevated risk for chronic diseases and premature death, concentrated within Black and Latinx populations. While the connection between SRD and health is well documented, few studies provide evidence on strategies to reduce SRD and mitigate consequences on psychological and physiological outcomes. Thus, there is a critical need to rigorously test interventions that improve the mental and physical health of Black and Latinx populations, beginning in adolescence. The study's specific aims are to 1) Determine whether a racial justice activism behavioral intervention prevents and reduces depressive symptoms in Black and Latinx adolescents and young adults and 2) Determine whether a racial justice activism behavioral intervention lowers allostatic load scores in Black and Latinx adolescents and young adults. To accomplish these aims, the team will conduct a stage II group-based, multi-component, and multilevel randomized behavioral clinical trial. The investigators will collect psychological and physiological measures at baseline, then at defined intervals for 2 years post the racial justice activism intervention.