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Life sciences · Observational Study
ClinicalTrials.gov · October 13, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT07871487). This is a study registration, not published results. Lead sponsor: Uppsala University Hospital. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 30 participants (ESTIMATED). Conditions: Postoperative Cognitive Dysfunction, Alzheimer Disease, Tauopathies, Neuroinflammation, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee. Interventions: PROCEDURE: Hip or Knee Arthroplasty Under Spinal Anesthesia. Primary outcome measures: Change in Tau Levels in the Hippocampus on PET Scan , baseline, 12 and 24 months; Change in Brain Tau Burden Measured by [18F]RO948 PET , 24 months. Brief summary: The goal of this observational study is to study whether major surgery is linked to changes in the brain that are typical of Alzheimer's disease. The study is a prospective observational study that will be carried out in Uppsala University Hospital. Adults aged 55-75 years who are healthy otherwise (ASA1) having a hip or knee replacement under spinal anesthesia, and a comparison group of people of the same age and sex with hip or knee arthrosis who are not having surgery will be included. The main questions it aims to answer are: * Does the amount of the protein tau in the brain increase in the two years after surgery? * Are changes in tau linked to inflammation in the blood and spinal fluid, and to changes in memory and thinking? Participants will: * Have brain scans (PET and MRI) before surgery and 12 and 24 months later * Give small samples of spinal fluid and blood * Complete memory and thinking tests at the same time points Researchers will compare the surgery group with the non-surgery group to see whether surgery is associated with more tau in the brain and with changes in memory and thinking.