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Life sciences · Observational Study
ClinicalTrials.gov · November 9, 2026
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Observational Study.
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Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT04517838). This is a study registration, not published results. Lead sponsor: Mayo Clinic. Recruitment status: TERMINATED. Study type: OBSERVATIONAL. Enrollment: 127 participants (ACTUAL). Conditions: Breast Adenocarcinoma, HER2-Positive Breast Carcinoma, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8. Interventions: PROCEDURE: Biospecimen Collection. Primary outcome measures: HER2 specific T-cell response and clinical response , Up to 16 weeks; Antibody response and clinical response , Up to 16 weeks. Brief summary: This study gathers information from the blood cells and tumor tissue during treatment with anti-HER2 therapies, such as trastuzumab, pertuzumab, lapatinib, or neratinib, in patients with HER2 positive stage I-IV breast cancer who are scheduled to start anti-HER2 therapy. The information gained from this study may help researchers better understand the relation between cell response and anti-HER2 therapies.