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Ocular Infections and Treatments · Journal article
Ijid Regions · September 1, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a descriptive molecular epidemiology survey of 175 S. aureus isolates (30 MRSA, 145 MSSA) from pediatric patients in Myanmar over 19 months, characterizing clone prevalence by MLST and genotyping. The study documents a shift away from previously dominant ST239 (CC8)-MRSA toward CC1 and ST121 MRSA, with PVL genes more frequent in MSSA than MRSA; this represents an observed trend without intervention or clinical outcome data.
Descriptive cross-sectional molecular epidemiology study. Pediatric patients in Myanmar from whom S. aureus isolates were obtained from various clinical specimens.. n = 175. Myanmar.
Total 175 S. aureus isolates collected over 19 months (Sep. 2023 to Mar. 2025); 30 MRSA and 145 MSSA with overall MRSA rate of 17% PVL genes detected at higher rate in MSSA (69%) than MRSA (43%) Among MRSA, CC1 dominant types (ST772 and ST2885) accounted for 47%; ST121 (CC121) and ST6 (CC5) were other common clones
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This study documents a temporal shift in S. aureus clone epidemiology in Myanmar children, with emergence of CC1 and ST121 MRSA and loss of previously dominant ST239. Clinicians should be aware of changing local clone prevalence for empirical therapy guidance, though the study does not provide clinical outcome data or treatment efficacy comparisons.
A single-centre, descriptive molecular epidemiology study of 175 isolates over 19 months documenting clone prevalence and resistance genes in pediatric S. aureus, without clinical outcomes or comparator groups.
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This study documents a temporal shift in S. aureus clone epidemiology in Myanmar children, with emergence of CC1 and ST121 MRSA and loss of previously dominant ST239. Clinicians should be aware of changing local clone prevalence for empirical therapy guidance, though the study does not provide clinical outcome data or treatment efficacy comparisons.
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ABSTRACT Objectives: Staphylococcus aureus is one of the leading causes of infectious diseases in humans. This study aimed to analyze the recent epidemiological trend of clones and genetic features of methicillin-resistant and susceptible S. aureus (MRSA/MSSA) isolates from children in Myanmar. Methods: S. aureus isolated from various specimens of pediatric patients were classified by genotyping schemes of MLST, coa, agr, spa, and SCC mec. Antimicrobial resistance genes were detected by uniplex/multiplex PCR, along with antimicrobial susceptibility testing by broth microdilution method. Results: A total of 175 S. aureus isolates (30 MRSA and 145 MSSA) and one S. argenteus were obtained during a 19 month-period (Sep. 2023 to Mar. 2025), with an MRSA rate of 17%. Panton-Valentine leukocidin (PVL) genes were detected at higher rate in MSSA (69%) than MRSA (43%). Among MRSA, CC1 (dominant types; ST772 and ST2885) was the major clonal group accounting for 47%, while other common clones were ST121 (CC121) and ST6 (CC5). The most dominant MSSA clone was ST121 (48%), including 86% of PVL-positive isolates, followed by ST88 (14%), and ST2990 (CC1) (9%). An S. argenteus was methicillin-susceptible and assigned as ST2250. In the present study, previously most common ST239 (CC8)-MRSA-III in 2017-2019 was not detected, whereas a growing prevalence was noted for CC1 and ST121 MRSA. Conclusions: The present study revealed the clonal structure of recent MRSA/MSSA isolates from pediatric patients and their potential changing trend in Myanmar.
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