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Life sciences · Journal article
Journal of Diabetes and Metabolic Disorders · July 3, 2026
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This cross-sectional study of 851 men aged 50+ found that triglyceride-glucose index and related anthropometric parameters (TyG-BMI, TyG-WC) showed positive associations with bone mineral density and negative associations with osteoporosis/low BMD after multivariate adjustment, though TyG-BMI was negatively associated with trabecular bone score. The findings are observational and do not establish causality or clinical utility.
Cross-sectional analysis. Adult male participants aged 50 years or more from the Bushehr Elderly Health program.. n = 851. Bushehr, Iran (from program name; specific geographic detail not stated in source text)..
Mean participant age 62.9 ± 8.4 years; 151 of 851 (17.74%) had osteoporosis TyG and related parameters (except TyG-WHtR) showed significant positive association with BMD at each bone site after multivariate adjustment TyG and related parameters (except TyG-WHtR) showed significant negative association with osteoporosis/low BMD
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The associations identified are observational and cross-sectional, limiting clinical interpretation. TyG parameters may warrant investigation as non-invasive markers of bone health in older men, but findings require prospective validation and mechanistic study before clinical application.
Cross-sectional observational study showing associations between TyG parameters and bone density in older men, but lacking causal inference, intervention, or comparison groups needed for stronger evidence grades.
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The associations identified are observational and cross-sectional, limiting clinical interpretation. TyG parameters may warrant investigation as non-invasive markers of bone health in older men, but findings require prospective validation and mechanistic study before clinical application.
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Background. The triglyceride-glucose (TyG) index and its related parameters (TyG-BMI, TyG-WC, and TyG-WHtR) have emerged as sensitive and cost-effective markers of insulin resistance (IR). However, limited research has investigated the association between these parameters with bone health. This study aimed to evaluate the association between TyG and its related parameters with bone mineral density (BMD), as surrogate markers of IR and bone health among men over 50 years utilizing data from the Bushehr Elderly Health (BEH) program.Methods. This cross-sectional analysis utilized data from the BEH Program involving 851 adult male aged 50 years or more. Bone health was assessed using BMD measurements at the lumbar spine, total hip, and femoral neck, and trabecular bone score (TBS). Low BMD (osteopenia/osteoporosis) and osteoporosis were defined as a T-score lower than 1 standard deviation (SD) below the reference mean (- 1 or lower) and 2.5 SD or more below reference mean (- 2.5 and lower) in at least one site, respectively.Results. The mean age of the study participants was 62.9 ± 8.4 years, of whom 151 (17.74%) had osteoporosis. Through multivariate linear and logistic regression analysis, TyG and its related parameters (except TyG-WHtR) exhibited a significant positive association with BMD and a negative association with osteoporosis/ low BMD at each bone site. Conversely, TyG-BMI showed negative association with TBS (p < 0.001) after adjustment for confounding factors.Conclusions. These findings highlighted that TyG index-related parameters may serve as valuable markers in evaluating bone health in older adult men.
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