Life sciences · Interventional Study
ClinicalTrials.gov · September 25, 2026
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Interventional Study.
No findings were extractable from the material analysed.
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Registry record from ClinicalTrials.gov (NCT07842601). This is a study registration, not published results. Lead sponsor: University of Kentucky. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Opioid Use Disorder, Major Depressive Disorder (MDD). Interventions: DEVICE: Transcranial Magnetic Stimulation (TMS); DEVICE: Sham Transcranial Magnetic Stimulation (TMS). Primary outcome measures: Change in Depressive Symptom Severity , Baseline through Week 13; Change in Opioid Craving , Baseline through Week 13. Brief summary: This study will compare transcranial magnetic stimulation (TMS) with sham TMS in people with opioid use disorder who are taking buprenorphine and have major depressive disorder with ongoing depressive symptoms. The study will evaluate whether TMS improves depressive symptoms and reduces opioid craving. The study will also assess smoking behaviors, treatment acceptability, and any side effects related to TMS.