Life sciences · Interventional Study
ClinicalTrials.gov · September 18, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07682207). This is a study registration, not published results. Lead sponsor: Lawson Research Institute of St. Joseph's. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 16 participants (ESTIMATED). Conditions: Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD). Interventions: DEVICE: Accelerated intermittent theta burst stimulation. Primary outcome measures: Recruitment rate , Study recruitment period, up to 12 months; Consent rate , Study recruitment period, up to 12 months; Treatment adherence , Treatment Days 1 through 5; Retention through Week 12 follow-up , Baseline through Week 12; Adverse events , Treatment Days 1 through Week 12; Serious adverse events , Treatment Days 1 through Week 12; Discontinuations due to adverse events , Treatment Days 1 through Week 12; Participant satisfaction with accelerated iTBS , Week 2, Week 5, and Week 12; Participant feedback on accelerated iTBS , Week 2, Week 5, and Week 12. Brief summary: The goal of this pilot clinical trial is to learn if a faster brain stimulation schedule is practical, safe, tolerable, and acceptable. This study looks at accelerated intermittent theta burst stimulation, or accelerated iTBS. This is a non-invasive type of magnetic brain stimulation. This study is for adults with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). The main questions this study aims to answer are: 1. Can participants complete six short brain stimulation sessions per day for five days? 2. Is this treatment schedule safe and tolerable for participants? 3. What changes occur in depression symptoms, PTSD symptoms, anxiety, quality of life, and brain activity over time? Participants will: 1. Complete health screening and baseline assessments. 2. Receive six short sessions of magnetic brain stimulation per day for five days. 3. Have their brain activity measured using an EEG recording. 4. Return for a post-treatment assessment at Week 2 and follow-up visits at Week 5 and Week 12.