Loading
Life sciences · Journal article
Neuroendocrinology · October 11, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Neuropeptides are small bioactive peptides secreted by neurons and immune cells that serve as critical messengers in both central and peripheral systems. Recent studies have identified key neuropeptides—such as Substance P (SP), Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), and Calcitonin Gene-Related Peptide (CGRP)—as pivotal regulators of immunometabolism and neuroinflammation. These peptides influence macrophage polarization, T cell differentiation, cytokine production, and neuroimmune crosstalk, linking chronic inflammation to conditions such as obesity, diabetes, autoimmunity, and neurodegeneration. This review synthesizes emerging evidence on Traditional Chinese Medicine (TCM) interventions—including herbal formulas, single herbs, bioactive compounds, and acupuncture—that modulate neuropeptide signaling via NF-κB, MAPK, and Nrf2 pathways. These mechanisms contribute to analgesia, emotional stabilization, metabolic regulation, and neuroprotection. The article further presents a modular framework connecting representative Chinese medicinal substances to specific neuropeptides and physiological functions, offering a translational foundation for neuropeptide-targeted therapies and integrative precision health strategies.