Symptom Review and Psychoeducation (SRP) / Engage & Connect (E&C) / Postpartum Depression · Interventional Study

Engage & Connect: A Psychotherapy for Postpartum Depression

ClinicalTrials.gov · August 20, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a registry record for an ongoing randomized controlled trial of a novel remote psychotherapy (Engage & Connect) versus symptom review and psychoeducation for postpartum depression. No results are yet available; the trial is actively recruiting and has not reported outcomes.

What was studied

Interventional, Randomized, Single Group, Double masking, Treatment purpose. Postpartum Depression; Female. Intervention: Engage & Connect; Symptom Review and Psychoeducation. Compared with: Symptom Review and Psychoeducation (SRP) delivered remotely. n = 60. 1 site: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is an ongoing trial registration with no results posted; it describes a planned small RCT (n=60) of a novel psychotherapy for postpartum depression that has not yet reported outcomes.

Study design

As stated by the source record.

MethodsPrimary outcome measure: Change in Edinburgh Postnatal Depression Scale (EPDS) (assessed at the EPDS will be measured Weekly for 9 weeks)

DesignInterventional, Randomized, Single Group, Double masking, Treatment purpose

PopulationPostpartum Depression; Female

Sample size60

InterventionEngage & Connect; Symptom Review and Psychoeducation

ComparatorSymptom Review and Psychoeducation (SRP) delivered remotely

Setting1 site: United States

Reported figures

Quoted from the source exactly as published.

Planned enrollment60

Primary outcome measureChange in Edinburgh Postnatal Depression Scale (EPDS), measured weekly for 9 weeks

Study duration9 weeks

Caveats

This is a registry record only; no results are reported and the trial is still recruiting.
Sample size (n=60) is small and no power calculation or justification is provided.
Phase not specified; allocation concealment, blinding method, and other methodologic details are not described.
Eligibility criteria, geographic location, and follow-up duration beyond the 9-week intervention period are not stated in this registry record.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Randomized controlled trial comparing two behavioral interventions; phase and allocation concealment not stated.

Directness

strong

Primary outcome is clinical (EPDS change); patient population is postpartum depression directly.

Consistency

insufficient

No results reported; consistency cannot be assessed from a registry record.

Risk of bias

insufficient

Blinding status, allocation concealment, and trial conduct details not described in registry.

Sample adequacy

limited

Planned enrollment is 60 participants; no sample size justification or power calculation stated.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT05585164). This is a study registration, not published results. Lead sponsor: Weill Medical College of Cornell University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Postpartum Depression. Interventions: BEHAVIORAL: Engage & Connect (E&C); BEHAVIORAL: Symptom Review and Psychoeducation (SRP). Primary outcome measures: Change in Edinburgh Postnatal Depression Scale (EPDS) , the EPDS will be measured Weekly for 9 weeks. Brief summary: This randomized controlled trial compares a novel psychotherapy, Engage \& Connect, with a Symptom Review and Psychoeducation intervention, tailored to reduce postpartum depression. The study includes 9-weeks interventions, delivered remotely. It will examine changes in social isolation, processing of social rewards and depression severity over 9 weeks of treatment.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

Symptom Review and Psychoeducation (SRP)NCT05585164Weill Medical College of Cornell UniversityEngage & Connect (E&C)Postpartum Depression