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Life sciences · Preprint
arXiv · September 23, 2026
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Multimodal learning (MML) falls into the optimization dilemma due to the modality imbalance phenomenon, leading to suboptimal overall performance in practice. While many attempts primarily focus on balancing the optimization dynamics across modalities to address this issue, we identify a subtle yet critical flaw: optimization yields asymmetric gains in predictive certainty, with the strong modality more confident than the weak one, driving imbalanced modality contributions. In this paper, our analysis reveals that this flaw stems from unimodal characteristics rather than multimodal learning, and this confidence discrepancy can be corrected by positive cross-modal intervention. Based on this insight, we propose multimodal Max Confidence Regularization (MaxCR) to dynamically intervene in modality semantic confidence. Specifically, the semantic confidence of each modality is tracked using a nonlinear sparsity measure. We then design max suppression and max excitation based on this measure to regularize strong and weak modalities, respectively. They penalize and encourage the top-1 confidence, thereby constraining multimodal prediction. To this end, strong and weak modalities are expected to make calibrated confidence, thereby improving the overall performance. Empirical experiments on widely used datasets reveal the superiority of our method through comparison with various state-of-the-art (SOTA) multimodal learning baselines.