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Life sciences · Phase 2 Trial
ClinicalTrials.gov · September 23, 2026
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Phase 2 Trial.
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Registry record from ClinicalTrials.gov (NCT06269146). This is a study registration, not published results. Lead sponsor: University of California, San Diego. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: PHASE2. Study type: INTERVENTIONAL. Enrollment: 108 participants (ESTIMATED). Conditions: Anxiety Disorders, Anxiety, Depression, Social Disconnection. Interventions: DRUG: Pramipexole Pill; DRUG: Placebo Pill. Primary outcome measures: Neural activation during social reward anticipation , Baseline, week 6. Brief summary: This study seeks to understand if the medication pramipexole improves social connectedness and functioning in adults (ages 18-50) who experience anxiety or depression. The study plans to enroll 108 participants total across two sites (University of California San Diego and New York State Psychiatric Institute). Pramipexole will be given in a 6-week randomized, double-blind, placebo-controlled trial. Social reward processing will be assessed using measures of brain function (fMRI), behavior, and self-report at baseline and week 6. Knowledge gained from this study will help determine the therapeutic potential of targeting the dopamine system to remediate social disconnection as an anxiety and depression intervention.