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Stomach Cancer / Colon and Rectum Cancer / Peptic Ulcer Disease · Journal article
Future Science Oa · July 8, 2026
Early or partial results. Treat as a signal, not a conclusion.
This global burden of disease analysis examined four digestive conditions from 1990 to 2021, revealing that gastritis and duodenitis had the highest age-standardized incidence and prevalence rates while colorectal cancer had the highest mortality and DALY rates in 2021. Over the 31-year period, colorectal cancer incidence and prevalence rose despite declining mortality, whereas stomach cancer, peptic ulcer disease, and gastritis/duodenitis showed declining trends across all metrics.
Systematic analysis of global burden of disease database. Global population data from GBD 2021, stratified by age groups, sexes, and regions. Global analysis with regional stratification (specific regions not enumerated in abstract).
In 2021, gastritis and duodenitis exhibited the highest ASIR and ASPR among the four digestive diseases analyzed Colon and rectum cancer presented the highest ASMR and ASDR in 2021 From 1990 to 2021, ASIR and ASPR of colon and rectum cancer demonstrated an upward trend while ASMR and ASDR declined
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Rising colorectal cancer incidence despite declining mortality suggests improved survival but ongoing need for enhanced screening and prevention. Declining trends in stomach cancer and peptic ulcer disease may reflect public health interventions and improved management, though regional disparities warrant targeted strategies.
Descriptive epidemiological analysis showing trends but lacking intervention data or causal inference to guide practice change.
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Quoted from the source exactly as published.
Rising colorectal cancer incidence despite declining mortality suggests improved survival but ongoing need for enhanced screening and prevention. Declining trends in stomach cancer and peptic ulcer disease may reflect public health interventions and improved management, though regional disparities warrant targeted strategies.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. Geographical disparities are evident in the burden of digestive system diseases. To date, however, a comparative analysis that simultaneously examines the burden of common digestive cancers alongside non-malignant conditions using the most recent GBD 2021 data is lacking. A comprehensive global assessment of the burden of digestive system diseases is therefore warranted.Methods. This study analyzed incidence, prevalence, mortality, and DALYs of four digestive system diseases from the GBD 2021 database. The incidence, prevalence, mortality, and DALYs were further examined across age groups, sexes, and regions. The ASIR, ASPR, ASMR, ASDR, and EAPC were used to evaluate the disease burden.Results. In 2021, gastritis and duodenitis exhibited the highest ASIR and ASPR, whereas colon and rectum cancer presented the highest ASMR and ASDR. From 1990 to 2021, the ASIR and ASPR of colon and rectum cancer demonstrated an upward trend, while its ASMR and ASDR declined. By contrast, all metrics for stomach cancer, peptic ulcer disease, and gastritis and duodenitis showed declining trends.Conclusion. The global burden of digestive diseases continues to pose a substantial public health challenge. Greater attention should be directed toward high-risk factors, early screening, and effective prevention and treatment strategies.
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