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Life sciences · Preprint
arXiv · October 22, 2026
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The interpretability of complex neural networks remains a critical challenge, especially for models already deployed in high-stakes domains. To address this, we adapted the Feature Selection Layer (FSL) to optimize feature weights post-training, a variant we term post-hoc FSL. Our approach reframes the FSL as a lightweight, trainable module that integrates with already frozen pre-trained models on tabular datasets to highlight the features the original model considers most important. This post-hoc FSL learns feature relevance by fine-tuning its weights based on the original model's learned outputs. Crucially, this process is non-invasive, operating without altering the original model's architecture or its learned parameters. We conducted our experiments using both statistical and visual metrics, including accuracy, F1 score, recall, precision, weighted t-SNE and silhouette score, and also analyzed the stability of the post-hoc FSL on high-dimensional synthetic and real-world tabular datasets. We compared the post-hoc FSL feature weighting method using these metrics against the original embedded FSL and other post-hoc interpretability methods, such as Integrated Gradients, Noise Tunnel, DeepLIFT, Gradient SHAP, and Feature Ablation. Experimental results demonstrate that the post-hoc FSL feature weighting method successfully identified relevant features across the different datasets, maintaining the predictive power of the original neural network while enhancing its interpretability.