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Echocardiographic Assessment / End Stage Heart Failure · Observational Study
ClinicalTrials.gov · September 9, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a recruiting prospective observational study registered to assess echocardiographic changes in left and right ventricular function in 24 patients with end-stage heart failure receiving Impella 5.5 support. No results have been posted in this registry record. The study measures surrogate endpoints (strain and myocardial work) at baseline, immediately post-initiation, and up to postoperative day 14.
Observational. End-stage Heart Failure; age from 18 Years. Intervention: End-stage heart failure patients receiving Impella 5.5. n = 24. 1 site: United States.
This is a recruiting prospective observational study registered to assess echocardiographic changes in left and right ventricular function in 24 patients with end-stage heart failure receiving Impella 5.5 support. No results have been posted in this registry record. The study measures surrogate endpoints (strain and myocardial work) at baseline, immediately post-initiation, and up to postoperative day 14.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
No clinical impact can be assessed from this registry record, as results are not yet posted. Once complete, findings on biventricular strain and myocardial work changes may inform understanding of Impella's acute hemodynamic effects, though clinical outcome data would be needed to guide practice.
This is an ongoing observational registry study with no results yet reported; it plans to enroll 24 participants and measure echocardiographic changes in biventricular function during Impella support.
As stated by the source record.
Quoted from the source exactly as published.
No clinical impact can be assessed from this registry record, as results are not yet posted. Once complete, findings on biventricular strain and myocardial work changes may inform understanding of Impella's acute hemodynamic effects, though clinical outcome data would be needed to guide practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07534462). This is a study registration, not published results. Lead sponsor: University of Rochester. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 24 participants (ESTIMATED). Conditions: End-stage Heart Failure. Interventions: DIAGNOSTIC_TEST: Echocardiographic Assessment. Primary outcome measures: Mean Change from Baseline in Left Ventricular Global Longitudinal Strain (LV GLS) , Baseline, immediately post-Impella initiation, and postoperative day up to Day 14; Mean Change from Baseline in Left Ventricular Myocardial Work (MW , Baseline, immediately post-Impella initiation, and postoperative day up to Day14; Mean Change from Baseline in Right Ventricular Global Longitudinal Strain (RV GLS) , Baseline, immediately post-Impella initiation, and postoperative day up to Day 14. Brief summary: The objective of this prospective observational study is to evaluate the effects of Impella 5.5 on biventricular function in adult patients with end-stage heart failure requiring temporary mechanical circulatory support. The study will assess changes in left and right ventricular global longitudinal strain and myocardial work, as well as additional echocardiographic and hemodynamic parameters. Measurements will be obtained at baseline prior to Impella implantation, immediately after device initiation, and during postoperative follow-up up to Day 14. This study involves collection of echocardiographic imaging and clinical data, including additional imaging performed for research purposes.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.