Nudging / Heart Failure · Interventional Study

Investigating the Impact of Nudging Cardiologists to Prescribe Guideline-directed Medical Therapy in Heart Failure Patients

ClinicalTrials.gov · August 10, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a prospective stepped wedge RCT (NCT06844006) designed to evaluate whether digital nudging directed at cardiologists improves guideline-directed medical therapy prescription and reduces heart failure hospitalizations and mortality over 15 months. No results have been posted in this registry record; the study is currently enrolling by invitation.

What was studied

Interventional, Single Group, Open label, Treatment purpose. Heart Failure; age from 18 Years. Intervention: Intervention. Compared with: Comparator condition not explicitly stated in registry record; stepped wedge design implies standard care or delayed intervention arm.. n = 1,320. 5 sites: Netherlands.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

The source did not state who this applies to in practice.

Plain-language summary

This is a planned interventional trial with no results posted; the registry record describes design and intended outcomes only, not empirical findings.

Study design

As stated by the source record.

MethodsPrimary outcome measures: HF related hospitalization (assessed at From enrollment to the end of the design (15 months).); All cause death (assessed at All cause death rate during the 15 month duration of the study.)

DesignInterventional, Single Group, Open label, Treatment purpose

PopulationHeart Failure; age from 18 Years

Sample size1,320

InterventionIntervention

ComparatorComparator condition not explicitly stated in registry record; stepped wedge design implies standard care or delayed intervention arm.

Setting5 sites: Netherlands

Reported figures

Quoted from the source exactly as published.

Planned sample size1320

Primary outcome 1HF related hospitalization, measured from enrollment to 15 months

Primary outcome 2All cause death rate during 15 month study duration

Follow-up duration15 months

Caveats

No results reported in this registry record; study is ongoing and enrolling by invitation.
Phase field listed as 'NA'; exact trial phase not specified in source.
Specific eligibility criteria not detailed in the registry summary.
No data on intervention fidelity, adherence measurement, or outcome definitions beyond primary outcome names.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

strong

Stepped wedge RCT design with explicit randomization stated.

Directness

strong

Hard clinical outcomes: HF hospitalization and all-cause mortality.

Consistency

insufficient

Registry record; no results reported for consistency assessment.

Risk of bias

insufficient

No results or methods detail sufficient to assess bias risk.

Sample adequacy

moderate

Estimated 1320 participants enrolled; adequate for primary outcomes.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT06844006). This is a study registration, not published results. Lead sponsor: Medisch Spectrum Twente. Recruitment status: ENROLLING_BY_INVITATION. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 1320 participants (ESTIMATED). Conditions: Heart Failure. Interventions: COMBINATION_PRODUCT: Nudging. Primary outcome measures: HF related hospitalization , From enrollment to the end of the design (15 months).; All cause death , All cause death rate during the 15 month duration of the study.. Brief summary: This study investigates the impact of a nudge-based intervention on improving guideline directed medical therapy (GDMT) prescription among cardiologists. Using a stepped wedge randomized controlled trial design, we assess whether digital decision support-leveraging home monitoring and clinical data-enhances adherence to guideline-recommended medication titration. The primary outcomes include HF related hospitalization rates and all cause mortality.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

NCT06844006NudgingMedisch Spectrum TwenteHeart Failure