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Life sciences · Journal article
Hitit Medical Journal · October 13, 2026
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Objective: Breast cancer remains a major cause of cancer-related mortality worldwide. Although doxorubicin (DOX) is widely used in breast cancer therapy, the emergence of resistance substantially reduces its clinical efficacy. Proton pump inhibitors (PPIs) may influence tumour biology by modulating the cellular microenvironment. This study aimed to evaluate the single-agent effects of pantoprazole and omeprazole on the viability of MCF-7 breast cancer cells adapted to increasing concentrations of doxorubicin.Materials and Methods: In this study, the human breast cancer cell line MCF-7 was utilized. Doxorubicin-adapted cells (MCF-7/DOX-A) were developed in vitro by exposing MCF-7 cells to gradually increasing concentrations of DOX. Following the adaptation protocol, the cells were used in subsequent experiments; a resistant phenotype was not independently verified. Pantoprazole and omeprazole were administered to the DOX-adapted MCF-7 cells at concentrations of 50, 25, 12.5, and 6.25 μM. Cell viability was evaluated using the XTT colorimetric assay, and the resulting data were subjected to statistical analysis. Statistical significance was defined as p0.05).Conclusion: Pantoprazole and omeprazole did not significantly alter the viability of MCF-7/DOX-A cells at the tested concentrations. These results do not exclude effects on other cellular outcomes.