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Life sciences · Interventional Study
ClinicalTrials.gov · October 29, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06875622). This is a study registration, not published results. Lead sponsor: The Miriam Hospital. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 490 participants (ESTIMATED). Conditions: Obesity/Therapy. Interventions: BEHAVIORAL: Automated online weight loss program; BEHAVIORAL: Individual coaching; BEHAVIORAL: Group-based, videoconference-delivered weight loss. Primary outcome measures: Percent weight change , 12 months; Change in perceived support , 12 months. Brief summary: The purpose of this trial is to compare two delivery formats for weight loss (automated online program vs. group-based videoconference program) and to examine the added effect of individual coaching (vs. no coaching) for individuals with overweight or obesity. All participants enrolled in this study will receive a 12-month behavioral weight loss program (varying in delivery format and individual support), and will be provided with weight loss, calorie intake, and exercise goals. Assessments will occur at baseline, 6 (mid-treatment), 12 (post-treatment), and 18 months (following 6 months of no intervention). We will also seek to determine which combination of intervention approaches works best for whom and develop algorithms which can be used to refer patients into remote programs in clinical settings or future trials.