Life sciences · Interventional Study
ClinicalTrials.gov · September 17, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT07824973). This is a study registration, not published results. Lead sponsor: Valdemar Landgren. Recruitment status: NOT_YET_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 120 participants (ESTIMATED). Conditions: Treatment Resistant Depression (TRD). Interventions: BEHAVIORAL: Psychedelic framing; BEHAVIORAL: Biomedical framing. Primary outcome measures: Change in depressive symptoms (MADRS total score) , Baseline to week 12. Brief summary: Ketamine is a medicine used in psychiatry for treatment-resistant depression. This study compares two ways of framing ketamine treatment: a psychedelic framing and a biomedical framing. The study will examine whether the framing affects depressive symptoms, treatment experience, tolerability, and longer-term outcomes.