Life sciences · Journal article
The Korean Society for Veterinary Nursing · September 21, 2026
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The canine gut microbiome is a dynamic ecosystem that develops rapidly after birth, matures during weaning and growth, becomes comparatively stable in adulthood, and changes heterogeneously with aging. Gut microorganisms contribute to fermentation of nondigestible substrates, production of short-chain fatty acids and indole derivatives, bile acid transformation, mucosal immune regulation, epithelial barrier maintenance, and colonization resistance. Early life is highly plastic and sensitive to maternal, dietary, infectious, and antimicrobial exposures, whereas adult health depends more on functional redundancy and ecological resilience than on a fixed taxonomic profile. In senior dogs, reported age-associated changes are inconsistent because they are strongly influenced by breed size, diet, obesity, activity, multimorbidity, oral health, and medication. This review focuses on microbiome development across life stages, the relationship between microbial function and gastrointestinal health, and practical approaches to preserve or improve microbial resilience. Evidence supports gradual dietary transitions, nutritionally complete diets, suitable fermentable fibers, maintenance of healthy body condition, parasite control, and prudent antimicrobial use. Probiotics, prebiotics, synbiotics, and postbiotics may be beneficial in selected settings, but effects are strain-, substrate-, dose-, diet-, and disease-specific. Longitudinal multi-omics studies with clinically relevant outcomes are needed before age-specific biomarkers or personalized microbiome interventions can be applied reliably in veterinary practice.