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Life sciences · Interventional Study
ClinicalTrials.gov · October 15, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06900608). This is a study registration, not published results. Lead sponsor: Western Michigan University. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 52 participants (ACTUAL). Conditions: Depression Disorder, Distress, Emotional. Interventions: BEHAVIORAL: Acceptance and Commitment Therapy; BEHAVIORAL: Treatment as usual. Primary outcome measures: Demographic Questionnaire , Pre-treatment; Rosenberg Self-Esteem Scale , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Brief Symptom Inventory-Global Severity Index , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Psychiatric Diagnostic Screening Questionnaire (PDSQ) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Beck Depression Inventory - II (BDI) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Acceptance and Action Questionnaire - II (AAQ-II) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Automatic Thoughts Questionnaire (ATQ) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Environmental Reward Observation Scale (EROS) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment; Valued Living Questionnaire (VLQ) , Pre-treatment, 3 weeks, 6 weeks/post-treatment, and 1 month after post-treatment. Brief summary: Acceptance and Commitment Therapy (ACT) has demonstrated efficacy in reducing depressive symptoms, primarily compared to no treatment or minimal treatment controls. This study compared the efficacy of ACT targeting cognitive defusion (CD, 3 sessions) and values-based activity scheduling (VBAS, 3 sessions) to supportive therapy (ST). Both treatments offered six sessions, a rationale for the approach, related techniques, and homework assignments. A parallel group randomized controlled efficacy trial design was used. Participants were stratified by gender identification and depression severity and then randomly allocated, according to a predetermined sequence, 2:1 to ACT or ST. Dependent measures were collected during acute treatment (pre, mid, and post-treatment) and follow-up at one-month.