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Life sciences · Preprint
arXiv · October 22, 2026
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The growth of time-series datasets and foundation models has made dataset comparison a central part of time-series workflows. Assessing source-target transfer before model adaptation requires similarity estimates that can summarize transfer-related dataset relationships without exhaustive source-target evaluation over every candidate pair. Many metrics have been proposed for measuring similarity between time-series datasets, but they capture different dataset relationships and vary in how well they align with downstream utility across tasks. We evaluate this gap by measuring the correlation between source-target similarity scores and downstream forecasting errors in out-of-distribution and transfer-learning settings. We propose Domain-Integrated Similarity Cost (DISC), a learnable aggregation framework that uses calibration transfer observations to select, weight, and combine similarity metrics for different downstream tasks. By integrating complementary metric values, DISC better distinguishes source-target dataset differences that matter for downstream behavior. After calibration, DISC scores source-target pairs using only their similarity-metric values and yields higher alignment than single-metric references on the reported split. These results show that time-series dataset similarity is task-dependent, and that learned metric integration provides a stronger proxy for downstream transfer behavior than manually selecting one similarity metric.