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Obesity / Adjusted Mixed Meal Test / Healthy Volunteer · Interventional Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned within-subject comparison study registered to evaluate whether fixed or energy-adjusted mixed meal test protocols produce different glucose variability in participants across a range of BMIs. No results have been posted in this registry record, and the study is currently recruiting.
Interventional, Randomized, Crossover, Single masking, Basic Science purpose. Obesity, Healthy Volunteer; age from 18 Years; to 99 Years; accepts healthy volunteers. Intervention: 1; 2. Compared with: Fixed Mixed Meal Test (standardized caloric dose for all participants). n = 79. 1 site: United States.
This is a planned within-subject comparison study registered to evaluate whether fixed or energy-adjusted mixed meal test protocols produce different glucose variability in participants across a range of BMIs. No results have been posted in this registry record, and the study is currently recruiting.
Phase designation listed as 'NA' suggests this is a methodological rather than efficacy or safety study.
This methodological study addresses an important gap in MMTT standardization across research protocols. Results, when available, may inform future guidance on whether meal dosing should be fixed or adjusted for body size in metabolic testing.
This is a registry record for an ongoing interventional study with no results posted; it describes a planned methodological comparison to optimize mixed meal test protocols.
As stated by the source record.
Quoted from the source exactly as published.
This methodological study addresses an important gap in MMTT standardization across research protocols. Results, when available, may inform future guidance on whether meal dosing should be fixed or adjusted for body size in metabolic testing.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT06223555). This is a study registration, not published results. Lead sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 79 participants (ESTIMATED). Conditions: Obesity, Healthy Volunteer. Interventions: OTHER: Fixed Mixed Meal Test; OTHER: Adjusted Mixed Meal Test. Primary outcome measures: To determine whether an adjusted energy dose MMTTor a fixed dosed meal will result in greater variability in glucose area under the curve (AUC) within the same participants across a range of BMIs. , Baseline, Visit 3/4. Brief summary: Background: Researchers use mixed meal tolerance tests (MMTTs) to look at how people s bodies respond to eating a meal. However, researchers do not agree on how to decide the number of calories to give in each meal. Some use fixed meals, which are the same size for everyone, and some use adjusted meals, based on the size of the person s body. Researchers want to know which MMTT is best to use for future research. Objective: To learn how fixed vs adjusted meals affect blood glucose levels in healthy people. Eligibility: Healthy people aged 18 years or older. Design: Participants will have 3 or 4 clinic visits of up to 8 hours in 8 weeks. Participants will have baseline tests: Their height, weight, and waist size will be measured. They will have an oral glucose tolerance test: A needle attached to a tube (IV) will be inserted into a vein in the arm. They will have a sugary drink. Blood samples will be taken from the tube at intervals up to 3 hours after the drink. They will have a body scan. Participants will have 2 MMTT visits. One will include a fixed meal and one will include an adjusted meal. They will have tests at both visits: Resting metabolic rate: A clear hood will be placed over the participant s head while they rest for 20 minutes. This will measure the oxygen they breathe in and out. MMTT. Participants will have 5 minutes to drink a liquid meal. Blood samples will be taken at intervals for the next 4 hours....
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.