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Life sciences · Interventional Study
ClinicalTrials.gov · September 14, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT06424132). This is a study registration, not published results. Lead sponsor: Rockefeller University. Recruitment status: ACTIVE_NOT_RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 80 participants (ESTIMATED). Conditions: Obesity, Metabolic Disease, Cold Exposure. Interventions: OTHER: Cold Vest Exposure Period; OTHER: Rewarming Exposure Period; OTHER: Fasting. Primary outcome measures: Identification of adipose tissue transcriptome , Before and after 3-hour rewarming period.; Identification of cold and warm-regulated proteome. , Before and after 3 hour cold exposure period and before and after 3 hour rewarming period.; Identification of cold and warm-regulated metabolome. , Time frame will be before and after 3 hour cold exposure period as well as before and after 3 hour rewarming period.. Brief summary: A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST). A critical limitation with NST as a therapeutic option, however, is that this beneficial process is silenced under human physiological temperature conditions and the mechanisms of how this occurs is unknown. This study will be the first to identify human NST silencing factors that may be targeted for the treatment of obesity and metabolic disorders.