Life sciences · Preprint
arXiv · October 22, 2026
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Automated manufacturing requires data-driven decisions under uncertainty and sparse observational records, and unplanned downtime is a dominant cost of getting them wrong. Prescriptive maintenance recommends a maintenance action against an impending failure rather than merely predicting it. Established reference architectures couple predictive models with rule- or optimisation-based recommendation logic. Selecting a corrective action, however, requires an interventional quantity: how the line behaviour would change if the action were set. Manufacturing data is observational, so a model fitted to predict the outcome estimates an associational quantity and may misdirect the choice of action without the prediction error revealing it. Causal estimators target the interventional quantity but require an expert-led causal study per case, for which the bounded decision window of operation leaves no room. This dissertation analyses how causal reasoning can be embedded into prescriptive maintenance so that actions are ranked by their estimated interventional effect. The result is PriMa-Causa, built from three components: a causal reasoning layer that integrates the estimate into the PriMa reference model, a parametric simulator that supplies the interventional ground truth absent from manufacturing data, and a graph-conditioned tabular causal foundation model that, pre-trained once on this synthetic production-line prior, answers interventional queries in a single forward pass. PriMa-Causa attains a lower prescription error than associational baselines, with the largest margin under weak overlap and sparse context, and a partially disclosed causal graph reduces this error further. The causal inductive bias of the synthetic prior and the graph conditioning can thus replace per-case estimator fitting, a step toward automating causal inference for autonomous and self-healing maintenance.