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Life sciences · Interventional Study
ClinicalTrials.gov · September 23, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Interventional Study.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
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Registry record from ClinicalTrials.gov (NCT05603923). This is a study registration, not published results. Lead sponsor: University of Illinois at Chicago. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 200 participants (ACTUAL). Conditions: Depression, Anxiety. Interventions: BEHAVIORAL: Lumen Coached PST Intervention.; BEHAVIORAL: Human Coached PST Intervention.; BEHAVIORAL: Optional (delayed) Lumen Coached PST (Waitlist control).. Primary outcome measures: Change From Baseline Functional Magnetic Resonance Scan at 18 Weeks , Baseline, 18 weeks. Brief summary: Approximately 200 Participants with mild-to-moderate, untreated depression and/or anxiety will be randomly assigned (by chance, like flipping a coin) to 1 of 3 study groups: Lumen Coached Problem-Solving Treatment (PST) (n=100), Human Coached PST (n=50), and optional (delayed) Lumen Coached PST as waitlist control (n=50) to improve emotional health. All participants will complete assessments at baseline and at 18 weeks post randomization. Depending on the group assignment the PST program will be delivered by Lumen, a virtual voice-based coach on a study iPad, or by a human coach in person for the first session and then via videoconference or phone for the remaining 7 sessions. Participants assigned to the waitlist control group can receive the Lumen coached PST on a study iPad after completing their 18-week follow-up assessment. Participants will receive 8 coaching sessions to learn problem-solving skills and work on unresolved problems in daily living that may be interfering with their emotional well-being and contributing to depression and anxiety symptoms.