Loading
Life sciences · Journal article
Frontiers in Endocrinology · September 28, 2026
No summary has been generated for this record yet. What follows is drawn from its source metadata only.
Journal article.
No findings were extractable from the material analysed.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
This record has not been graded across any dimension yet. Treat the label above as provisional and read the source.
What is missing. This record has no bottom line, key findings, reported figures, evidence dimensions. That is a gap in the analysis, not a judgement about the study.
Objective To evaluate the efficacy and safety of an Eastern Healthy Dietary Pattern (EHDP)-modified ketogenic diet in Chinese patients with obesity and polyendocrine metabolic ovarian syndrome (PMOS; formerly polycystic ovary syndrome [PCOS]) and to provide evidence for a culturally adapted nutritional intervention. Methods This single-arm, self-controlled study enrolled 55 patients with PMOS and obesity (body mass index [BMI] ≥28 kg/m²) from the Clinical Nutrition Clinic of the Second Affiliated Hospital of Zhejiang Chinese Medical University between February 2024 and September 2025. Participants underwent a 12-week phased dietary intervention. Body composition, metabolic indices, reproductive hormones, and clinical symptoms were assessed before and after the intervention. Results During the intervention, blood β-hydroxybutyrate concentrations remained within the target range of 0.5-3.0 mmol/L and reached 1.24 ± 0.41 mmol/L at week 12, indicating good adherence. Mean body weight decreased by 9.97 kg (10.63%), body fat mass by 7.53 kg, and visceral fat area by 35.81 cm², whereas skeletal muscle mass decreased by 1.60 kg. The homeostasis model assessment of insulin resistance (HOMA-IR) decreased by 48.8%, and triglyceride concentrations decreased from 1.60 ± 0.91 to 1.08 ± 0.49 mmol/L. Alanine aminotransferase and aspartate aminotransferase concentrations also decreased significantly, whereas low-density lipoprotein cholesterol and small dense low-density lipoprotein cholesterol did not increase significantly. Total testosterone and luteinizing hormone concentrations decreased by 35.8% and 55.5%, respectively, and the luteinizing hormone/follicle-stimulating hormone ratio approached the normal range. Serum 25-hydroxyvitamin D increased from 17.86 ± 3.52 to 23.90 ± 4.12 ng/mL. Clinical symptoms improved, with no clinically significant adverse changes in the assessed safety parameters (all P > 0.05). Conclusion A 12-week EHDP-modified ketogenic diet was associated with improvements in body composition, metabolic indices, reproductive hormones, and clinical symptoms in Chinese patients with PMOS and obesity, without clinically significant safety concerns. This culturally adapted approach may offer a practical nutritional strategy for this population; controlled trials are warranted to confirm these findings. Clinical trial registration https://www.chictr.org.cn/showproj.html?proj=176830, identifier ChiCTR2200063473.