Life sciences · Preprint
arXiv · September 30, 2026
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Time-series forecasting models achieve strong benchmark performance but exhibit severe systematic bias in industrial deployments. This train--deploy gap is conventionally attributed to temporal-structural errors or distribution shifts. We characterize a complementary source that these explanations overlook: canonical losses embed fixed statistical priors, while industrial demand mixes benign and pathological regimes---zero-inflation, skewness, high variability---in which these priors are systematically violated. The induced bias persists even under perfect temporal modeling, remains in a distributional-shape component that normalization cannot remove, and creates an aggregation trade-off invisible to aggregate metrics. We turn these observations into an evaluation toolkit centered on the Regime-wise Relative Bias Vector (RBV): a metric-agnostic, regime-decomposed diagnostic that audits how pooled training allocates systematic mismatch across pathological subpopulations. A controlled attribution analysis decomposes RBV into a model-independent intrinsic floor, set by each loss's estimand, and an excess component attributable to training, tracing observed bias to the loss rather than the model. A large-scale study---13 loss objectives, 3 seeds, 60,000+ series spanning RetailShiftBench and M5, with random-split controls---shows that regime-aware diagnosis separates optimization-type from bias-type failure, and that regime-aware training resolves the pooling-induced bias that capacity scaling cannot, for mean-type losses. A formal structural observation, that risk under evaluation-distribution contamination is affine in the pathology mixture weight, grounds these findings. Our work complements model ranking with mechanism-grounded, regime-oriented evaluation.