Life sciences · Preprint
arXiv · November 6, 2026
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Decision-focused learning trains prediction models to improve downstream decisions, but many methods require costly solver calls or optimal-solution labels. We propose a solver-free decision-focused learning framework for NP-hard edge-selection problems with uncertain parameters in the objective, the constraints, or both. A neural optimization layer is first trained without solution labels, using problem objectives and constraint penalties. Graph-informed edge scoring and iterative refinement encourage concentrated and structurally consistent continuous decisions. The layer is then frozen, and a prediction model is trained through its continuous output using a problem-specific loss evaluated under observed parameters. At deployment, the predictor, optimization layer, and a lightweight decoder produce decisions without solving the original NP-hard problem. Experiments on the asymmetric traveling salesperson and endpoint-free orienteering problems show consistently better decision quality than prediction-focused learning and improvements over most evaluated decision-focused baselines. Our framework requires less training time than the evaluated decision-focused baselines, even when optimization-layer pretraining is included. Neural deployment also produces decisions faster than solver-based deployment, offering a better quality-efficiency trade-off. The layer also reduces training cost in existing decision-focused methods when used as an approximate optimization oracle.