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One Lung Ventillation (OLV) / Lung Cancer (suspected Or Confirmed) / Quality of recovery scale · Observational Study
ClinicalTrials.gov · September 10, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registered but not yet recruiting observational feasibility study designed to characterize right ventricular haemodynamic changes during and after thoracoscopic lung cancer surgery using cardiac MRI, right heart catheterisation, and biomarkers. No results are available; the study aims to clarify measurement approaches and mechanistic pathways before a future intervention trial.
Observational. Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy, One Lung Ventillation (OLV); age from 18 Years. Intervention: Contrast cardiac magnetic resonance imaging; Right heart catheterisation; Perioperative plasma sampling; Quality of recovery scale. n = 15. Golden Jubilee National Hospital, Scotland, UK..
This is a registered but not yet recruiting observational feasibility study designed to characterize right ventricular haemodynamic changes during and after thoracoscopic lung cancer surgery using cardiac MRI, right heart catheterisation, and biomarkers. No results are available; the study aims to clarify measurement approaches and mechanistic pathways before a future intervention trial.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This feasibility study will not directly change clinical practice. Its results may inform the design and outcomes for a future therapeutic trial testing perioperative drugs to reduce right ventricular afterload in lung surgery.
This is a planned observational feasibility study with no results yet reported; it aims to establish measurement methods and characterize haemodynamic changes, not to test a therapeutic intervention or confirm clinical benefit.
As stated by the source record.
Quoted from the source exactly as published.
This feasibility study will not directly change clinical practice. Its results may inform the design and outcomes for a future therapeutic trial testing perioperative drugs to reduce right ventricular afterload in lung surgery.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07812207). This is a study registration, not published results. Lead sponsor: University of Glasgow. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 15 participants (ESTIMATED). Conditions: Lung Cancer (Suspected or Confirmed), Thoracoscopic Lobectomy, One Lung Ventillation (OLV). Interventions: DIAGNOSTIC_TEST: Contrast cardiac magnetic resonance imaging; DIAGNOSTIC_TEST: Right heart catheterisation; DIAGNOSTIC_TEST: Perioperative plasma sampling; OTHER: Quality of recovery scale. Primary outcome measures: Proportion of patients for whom meaningful haemodynamic data is obtained at clinically relevant timepoints , 24 hours. Brief summary: Lung cancer is a leading cause of cancer death in Scotland and the UK. Surgery, typically using a keyhole approach, provides the best chance of cure. Golden Jubilee National Hospital performs over 600 operations each year, making this the busiest lung surgery department in the country. Unfortunately, some patients suffer disabling breathlessness and a limited ability to perform even very gentle exercise after surgery, even if they had no breathing problems before surgery. Understanding the causes and preventing this breathlessness is the focus of this research. Despite advances in techniques, lung cancer surgery can result in long-term weakening of the muscular chamber of the right (-hand side of the) heart which pumps blood to the lungs. During surgery, the pressure against which this pump works increases, making it more difficult to push blood into the lungs. Even after surgery, when the pressure returns to normal, the right heart can remain weak. This weakening can contribute to breathlessness and exercise limitation. Preventing or reducing this right heart weakening may improve quality of life after surgery. The investigators are interested in understanding why this weakening occurs after lung surgery and then to develop treatments to prevent it. The answer may lie in reversing the high resistance against which the heart pumps during surgery. Ultimately, the aim is to improve patients' recovery from surgery and improve both breathing and the ability to exercise. This problem may be treatable with existing drugs which are proven to be safe, easy to deliver and are already available. These drugs can be given around the time of surgery. This study will not involve administering new treatments, though future clinical trial(s) are anticipated. Participants' care will be the same as is usually provided. Participants taking part will undergo more tests and monitoring than usual to help understand the changes taking place during and after surgery. Before a drug trial to test this idea, there are some key things to clarify . This study plans to recruit 15 participants having keyhole lung cancer surgery. The following will be performed: * Blood Tests: blood samples before and after surgery to check for heart injury. * Heart monitoring: temporarily insert a thin tube called a right heart catheter into a large blood vessel in the participants' neck the morning of surgery. This will allow continuous measurement of the pressure in the right heart and lung blood vessels. This will help design and deliver treatments, and how best to measure the effects. This heart catheter will be removed the day after surgery. * Heart scans: perform magnetic resonance imaging (MRI) scans before and after surgery to measure blood flow and examine the impact of surgery on the heart.
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