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Serial NT-proBNP Measurement / Acute Decompensated Heart Failure (ADHF) · Observational Study
ClinicalTrials.gov · August 13, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a planned observational study registered but not yet recruiting. It aims to evaluate the association between serial NT-proBNP changes and clinical decongestion in acute decompensated heart failure patients receiving standard care. No results are available; the registry record describes intended methodology and primary outcome measures only.
Observational. Acute Decompensated Heart Failure (ADHF); age from 18 Years. Intervention: Acute Decompensated Heart Failure Cohort. n = 50.
This is a planned observational study registered but not yet recruiting. It aims to evaluate the association between serial NT-proBNP changes and clinical decongestion in acute decompensated heart failure patients receiving standard care. No results are available; the registry record describes intended methodology and primary outcome measures only.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a registry record for a planned observational study with no results reported; it describes intended enrollment and outcome measures only, representing early-stage hypothesis generation rather than evidence of clinical effect.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07762521). This is a study registration, not published results. Lead sponsor: Mao Chen. Recruitment status: NOT_YET_RECRUITING. Study type: OBSERVATIONAL. Enrollment: 50 participants (ESTIMATED). Conditions: Acute Decompensated Heart Failure (ADHF). Interventions: OTHER: Serial NT-proBNP Measurement. Primary outcome measures: Percentage Change in NT-proBNP Levels From Baseline During Hospitalization , Within 72 hours after admission to the cardiac intensive care unit. Brief summary: The goal of this observational study is to investigate the association between dynamic changes in NT-proBNP levels and clinical decongestion status in patients with acute decompensated heart failure (ADHF) receiving guideline-directed standard medical treatment. The main question it aims to answer is: Among patients with acute decompensated heart failure treated according to current clinical guidelines, are changes in NT-proBNP levels during hospitalization associated with successful clinical decongestion? Participants will receive standard-of-care treatment for ADHF according to treating physicians' clinical decisions and current guideline recommendations. During hospitalization, serial NT-proBNP measurements and repeated assessments of congestion status will be performed to evaluate the relationship between NT-proBNP dynamics and the process of decongestion. This study is purely observational and will not assign treatments or modify clinical management. The findings may improve understanding of the role of NT-proBNP dynamics as a marker of treatment response and provide preliminary evidence for future studies on individualized management of acute heart failure.
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