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Life sciences · Preprint
arXiv · October 8, 2026
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Variational quantum algorithms are often limited by barren plateaus: gradients vanish as circuit size and depth increase, making quantum neural networks difficult to train. We propose Q-Capsule, a localized capsule-based quantum neural architecture that mitigates this problem through register partitioning, local readout, sparse inter-capsule coupling, trainable data re-uploading, and Quantum Fisher Information Matrix (QFIM)-guided adaptive depth growth. By restricting the dominant support of each observable to a small capsule and controlling inter-capsule entanglement, Q-Capsule preserves useful gradient signals while retaining communication between local quantum representations. As the register width increases, Q-Capsule consistently maintains stable gradient variance, whereas globally entangling baselines exhibit exponential suppression with a log-gradient-variance slope near -ln 2 per qubit. Q-Capsule also produces more structured optimization landscapes, higher parameter efficiency, improved robustness to depolarizing noise, and lower measurement requirements. Its adaptive policy achieves 98.1% accuracy on binary classification and 97.7% on four-class classification, while using approximately 73% fewer two-qubit gates than the fixed-deep model on the multiclass task.