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Acute Myocardial Infarction / Psychological, Cognitive, and Patient-Reported Outcome Assessments / Subclinical Depression · Interventional Study
ClinicalTrials.gov · September 4, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record for an active exploratory study designed to estimate the prevalence of subclinical depression (PHQ-9 score 5–9) in patients with first acute myocardial infarction and to explore associations with inflammatory, metabolic, autonomic, and cardiac outcomes over 12 months. No results are reported in this registry entry; the study is currently recruiting and is intended to generate preliminary descriptive data to support future confirmatory trials.
Interventional, Non Randomized, Parallel, Open label, Other purpose. Acute Myocardial Infarction, Subclinical Depression; age from 18 Years. Intervention: AMI + Subclinical Depression group; AMI NO Subclinical Depression Group. n = 100. 1 site: Italy.
This is a registry record for an active exploratory study designed to estimate the prevalence of subclinical depression (PHQ-9 score 5–9) in patients with first acute myocardial infarction and to explore associations with inflammatory, metabolic, autonomic, and cardiac outcomes over 12 months. No results are reported in this registry entry; the study is currently recruiting and is intended to generate preliminary descriptive data to support future confirmatory trials.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This preliminary descriptive study is not designed to test efficacy or change practice. Clinicians should monitor for publication of prevalence estimates and biomarker associations, which may motivate future randomized trials of depression screening and integrated mental health interventions in acute MI.
This is a registry record for an ongoing exploratory study with no reported results; it describes planned enrollment and assessment methods for investigating subclinical depression prevalence in acute MI, generating descriptive data to inform future trials.
As stated by the source record.
Quoted from the source exactly as published.
This preliminary descriptive study is not designed to test efficacy or change practice. Clinicians should monitor for publication of prevalence estimates and biomarker associations, which may motivate future randomized trials of depression screening and integrated mental health interventions in acute MI.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07492537). This is a study registration, not published results. Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 100 participants (ESTIMATED). Conditions: Acute Myocardial Infarction, Subclinical Depression. Interventions: OTHER: Psychological, Cognitive, and Patient-Reported Outcome Assessments. Primary outcome measures: Prevalence of Subclinical Depression in Patients with First Acute Myocardial Infarction , Baseline (hospital admission). Brief summary: This is an exploratory, prospective, non-profit study (SUBDIMA) designed to investigate the prevalence and potential prognostic significance of subclinical depression in patients admitted with a first acute myocardial infarction (AMI). Subclinical depression refers to the presence of mild depressive symptoms (PHQ-9 score 5-9) that do not meet DSM-5 TR criteria for major depressive disorder but may still be clinically relevant. The primary aim is to estimate the prevalence of subclinical depression in this setting. Secondary, exploratory objectives include evaluating associations with inflammatory and metabolic biomarkers, autonomic dysfunction, cardiac function, cognitive performance, quality of life, treatment adherence, and the risk of recurrent cardiovascular events over 12 months. The study is expected to generate new descriptive data that may inform future confirmatory trials and support early, personalized approaches to integrated cardiac and mental health care.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.