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Life sciences · Observational Study
ClinicalTrials.gov · September 17, 2026
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Observational Study.
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Registry record from ClinicalTrials.gov (NCT06597331). This is a study registration, not published results. Lead sponsor: Sahlgrenska University Hospital. Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 200 participants (ESTIMATED). Conditions: Chronic Obstructive Pulmonary Disease, Takotsubo Cardiomyopathy, Acute Heart Failure. Primary outcome measures: Reversible left ventricular dysfunction (myocardial stunning) according to echocardiography , 30 days; Clinical signs of acute heart failure at inclusion (day 0) or day 1 according to the Killip Classification , 2 days. Brief summary: The goal of this prospective observational study is to investigate to what extent acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) triggers Takotsubo-stunning, and how this affects the outcome for these patients. The main questions it aims to answer are: 1. What is cumulative incidence of Takotsubo-stunning in patients hospitalized for AE-COPD at Sahlgrenska University Hospital/S (Gothenburg, Sweden)? 2. Among patients hospitalized for AE-COPD at Sahlgrenska University Hospital/S, what is the risk of in-hospital clinical manifestations of acute heart failure in patients with Takotsubo-stunning compared to those without?