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Chronic Graft Versus Host Disease / Dental Plaque sampling / Dental Cleaning · Interventional Study
ClinicalTrials.gov · August 12, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a prospective interventional study registered to evaluate whether post-transplant dental cleaning reduces the risk of moderate-to-severe chronic graft-versus-host disease in allogeneic hematopoietic cell transplant recipients. No results are yet reported in this registry record; the trial is currently recruiting. The hypothesis is based on observational evidence that dental plaque bacteria may influence chronic GVHD development.
Interventional, Single Group, Open label, Prevention purpose. Chronic Graft Versus Host Disease, Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm; age from 18 Years. Intervention: Prevention (dental cleaning). n = 45. 1 site: United States.
This is a prospective interventional study registered to evaluate whether post-transplant dental cleaning reduces the risk of moderate-to-severe chronic graft-versus-host disease in allogeneic hematopoietic cell transplant recipients. No results are yet reported in this registry record; the trial is currently recruiting. The hypothesis is based on observational evidence that dental plaque bacteria may influence chronic GVHD development.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
If results show efficacy, post-transplant dental cleaning could become a simple, non-toxic addition to HCT supportive care to reduce chronic GVHD incidence. However, clinicians should await completion and results before changing practice.
This is a prospective interventional study registered but not yet reporting results; it evaluates feasibility and effectiveness of a novel preventive procedure in a small, single-centre cohort with a surrogate clinical outcome.
As stated by the source record.
Quoted from the source exactly as published.
If results show efficacy, post-transplant dental cleaning could become a simple, non-toxic addition to HCT supportive care to reduce chronic GVHD incidence. However, clinicians should await completion and results before changing practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07535008). This is a study registration, not published results. Lead sponsor: Fred Hutchinson Cancer Center. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 45 participants (ESTIMATED). Conditions: Chronic Graft Versus Host Disease, Acute Graft Versus Host Disease, Hematopoietic and Lymphatic System Neoplasm. Interventions: PROCEDURE: Dental Cleaning; PROCEDURE: Dental Plaque sampling. Primary outcome measures: Probability of moderate-to-severe chronic graft versus host disease , At 1-year post-transplant. Brief summary: This clinical trial evaluates the feasibility and effectiveness of a post-transplant dental cleaning for the prevention of chronic graft versus host disease (GVHD) in patients undergoing an allogeneic hematopoietic cell transplant (HCT). HCT is the only curative treatment for some types of blood cancer. Unfortunately, this approach can lead to the development of GVHD, which is a disease caused when cells from a donated stem cell graft attack the normal tissue of the transplant patient. Some research has shown that the bacteria that is present in the dental plaque soon after transplant may affect the development of chronic GVHD. Dental cleanings prior to transplant are part of the normal standard of care for patients undergoing HCT. Adding an additional cleaning shortly after HCT may be effective for preventing the development of chronic GVHD.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.