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Life sciences · Interventional Study
ClinicalTrials.gov · September 22, 2026
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Interventional Study.
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Registry record from ClinicalTrials.gov (NCT05879887). This is a study registration, not published results. Lead sponsor: University of Alabama at Birmingham. Recruitment status: COMPLETED. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 32 participants (ACTUAL). Conditions: Chronic Illness, Heart Failure - NYHA II - IV. Interventions: BEHAVIORAL: UPHOLDS (Utilizing Palliative Care for Heart Failure Optimized using Lay Navigators to Decrease Suffering). Primary outcome measures: Feasibility of Intervention Delivery and Data Collection , Baseline to 24 weeks; Acceptability of Intervention and Study Procedures , Baseline to 24 weeks. Brief summary: Using a highly innovative methodology, the Multiphase Optimization Strategy (MOST), the purpose of this randomized factorial pilot trial is to identify feasibility, acceptability, and preliminary efficacy of components of an intervention (UPHOLDS) to improve quality of life of older adults with advancing heart failure. Using a 2x2x2x2 factorial design, 64 adults with advancing heart failure will be randomized to receive one or more palliative care coach-delivered components, based on Ferrans' Health-Related Quality of Life Model: 1) psychoeducation on palliative care principles (4 vs. 8 sessions); 2) financial coaching (yes vs. no); 3) one-time specialty outpatient palliative care consultation (yes vs. no); and monthly follow (1 monthly follow-up call vs. monthly follow-up calls for 24 weeks).