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Life sciences · Journal article
World Journal of Gastrointestinal Surgery · October 16, 2026
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BACKGROUNDColorectal cancer is one of the major malignant tumors worldwide.Previous studies have shown that long noncoding RNAs have significant effects on various human cancers, but the underlying molecular mechanisms remain unclear. AIMTo investigate the impact of the long noncoding RNA Linc00909 on colorectal cancer and its molecular mechanism. METHODSUsing 196 paired colorectal cancer and adjacent tissues from 30 patients with rectal cancer (19 resistant, 11 sensitive) to neoadjuvant chemoradiotherapy, we assessed Linc00909 expression via real-time polymerase chain reaction and correlated it with survival outcomes.Functional assays in Linc00909-overexpressing SW620 and DLD1 cellsincluding cholecystokinin-8, flow cytometry, and sphere formation -evaluated proliferation, cell cycle, apoptosis, stemness, and 5-FU/radiotherapy sensitivity.Tumorigenicity was examined in vivo.Bioinformatics and molecular experiments explored Linc00909's ceRNA mechanism. RESULTSLinc00909 was upregulated in resistant and tumor tissues and independently predicted poorer overall and disease-free survival.Linc00909 overexpression enhanced proliferation, colony formation, antiapoptotic capacity, stemness, and therapy resistance in vitro, and promoted tumor growth in vivo.miR-625-5p was bioinformatically predicted and experimentally validated as a binding target of Linc00909, with its expression decreasing upon Linc00909 overexpression.SOX2 was identified as a downstream target 4 / 42 of miR-625-5p and showed increased expression at both mRNA and protein levels following Linc00909 upregulation. CONCLUSIONLinc00909 can affect the proliferation, colony formation, apoptosis, cell cycle regulation, spheroid formation ability, and sensitivity of colorectal cancer cells to 5-FU and radiotherapy.Mechanistically, Linc00909 may regulate the expression of the downstream target gene SOX2 by adsorbing miR-625-5p, thereby influencing the sensitivity of colorectal cancer cells to radiotherapy and chemotherapy.Therefore, Linc00909 can be considered a potential therapeutic target for treating colorectal cancer.